DIGITAL MARKETING STRATEGIES FOR NEXT-GENERATION FILM DISTRIBUTION

Digital distribution led to the rise of next-generation filmmakers, whose content (both short and feature length) was created for and distributed to online audiences (Ryan & Hearn, 2010). Independent companies and large studios (Netflix, Amazon Studios, Hulu) producing next-genera- tion film do not rely on theatrical success, since they work on micropayment, subscription or advertising-driven business models. This paper includes a literary review that maps the digital marketing strategies over the purchase journey, and define key performance indicators for each digital marketing strategy. To explore how next-generation film distributors are currently employing digital marketing strategies, a survey and a multiple case study methodology was designed and then implemented. The findings of the literary review, the survey, and case study are used to point out the limitations, industry challenges and research opportunities in the field of next-generation cinema.Digital distribution led to the rise of next-generation filmmakers, whose content (both short and feature length) was created for and distributed to online audiences (Ryan & Hearn, 2010). Independent companies and large studios (Netflix, Amazon Studios, Hulu) producing next-genera- tion film do not rely on theatrical success, since they work on micropayment, subscription or advertising-driven business models. This paper includes a literary review that maps the digital marketing strategies over the purchase journey, and define key performance indicators for each digital marketing strategy. To explore how next-generation film distributors are currently employing digital marketing strategies, a survey and a multiple case study methodology was designed and then implemented. The findings of the literary review, the survey, and case study are used to point out the limitations, industry challenges and research opportunities in the field of next-generation cinema

Small particle-size talc is associated with poor outcome and increased inflammation in thoracoscopic pleurodesis

Rationale: Talc is very effective for pleurodesis, but there is concern about complications, especially acute respiratory distress syndrome. Objectives: It was the aim of this study to investigate if talc with a high concentration of small particles induces greater production of cytokines, and if pleural tumor burden has any influence on the local production and spillover of cytokines to the systemic circulation and eventual complications. Methods: We investigated 227 consecutive patients with malignant effusion submitted to talc pleurodesis. One hundred and three patients received 'small-particle talc' (ST; containing about 50% particles <10 ¿m) and 124 received 'large-particle talc' (with <20% particles <10 ¿m). Serial samples of both pleural fluid and blood were taken before and 3, 24, 48 and 72 h after thoracoscopy. Also, mesothelial cells were stimulated with both types of talc in vitro. Measurements and Results: Interleukin-8, tumor necrosis factor-¿, vascular endothelial growth factor, basic fibroblast growth factor and thrombin-antithrombin complex were measured in all samples. Early death (<7 days after talc) occurred in 8 of 103 patients in the ST and in 1 of 124 in the 'large-particle talc' group (p = 0.007). Patients who received ST had significantly higher proinflammatory cytokines in pleural fluid and serum after talc application, and also in supernatants of the in vitro study. Pleural tumor burden correlated positively with proinflammatory cytokines in serum, suggesting that advanced tumor states induce stronger systemic reactions after talc application. Conclusions: ST provokes a strong inflammatory reaction in both pleural space and serum, which is associated with a higher rate of early deaths observed in patients receiving it.Instituto de Salud Carlos III FIS 04/028

Alta prevalência de hipertensão arterial na área de abrangência da equipe de saúde São José do município de Icaraí de Minas - Minas Gerais

A hipertensão arterial sistêmica (HAS) constitui um fator de risco de outras doenças como, as cardiovasculares, renais, cerebrais, que são importantes causas de morbilidade e mortalidade, considerando ser um sério problema de Saúde. A abordagem dos fatores de risco que interferem nesta doença deve ser uma das prioridades da Saúde Pública, sobretudo na Atenção Primaria. A prevenção é uma das estratégias mais efetivas para lograr uma boa qualidade de vida. A educação em saúde, o diagnóstico precoce e a abordagem terapêutica são fundamentais para controle adequado e diminuição das taxas de complicações provocadas pela HAS. Devido ao numero cada vez mais crescente de pessoas que convivem, ou tem os fatores de risco para padecer esta doença é que se requer da atenção das equipes de saúde assim como do autocuidado e da responsabilização do usuário que padece a doença. A Equipe de Saúde da Família São José, do município de Icaraí de Minas, no estado de Minas Gerais, depois de processados os dados de análise da situação de saúde da área da abrangência que atende, identificou como problema prioritário a alta prevalência de pessoas com HAS ou em risco. Como parte final do Curso de Especialização em Estratégia Saúde da Família é apresentado um Projeto de Intervenção, no método do Planejamento Estratégico Situacional, em que um plano de ação mostra os passos de atuação em nós críticos: (1) Baixo nível de informação da comunidade, (2)Melhora de hábitos e estilos de vida, (3)Uso incorreto dos medicamentos, (4)Melhora da estrutura dos serviços da saúde, e (5)Organização do processo de trabalho da Equipe da Saúde da Família. Para cada nó crítico é apresentado um projeto/operação, com descrição de resultados e produtos esperados, recursos necessários e recursos críticos, controle dos recursos, ações estratégicas, responsabilidades e prazos. Em conclusão, ressalta-se a importância da percepção da equipe de saúde na preparação de um plano de ação para a processo educativo da comunidade e da equipe, bem como e para a organização do processo de trabalho. Espera-se que a proposta permita intervenção com sucesso, sobre tudo em fatores de risco e na prevenção, controle e tratamento da doença

Small particle-size talc is associated with poor outcome and increased inflammation in thoracoscopic pleurodesis

Rationale: Talc is very effective for pleurodesis, but there is concern about complications, especially acute respiratory distress syndrome. Objectives: It was the aim of this study to investigate if talc with a high concentration of small particles induces greater production of cytokines, and if pleural tumor burden has any influence on the local production and spillover of cytokines to the systemic circulation and eventual complications. Methods: We investigated 227 consecutive patients with malignant effusion submitted to talc pleurodesis. One hundred and three patients received 'small-particle talc' (ST; containing about 50% particles <10 ¿m) and 124 received 'large-particle talc' (with <20% particles <10 ¿m). Serial samples of both pleural fluid and blood were taken before and 3, 24, 48 and 72 h after thoracoscopy. Also, mesothelial cells were stimulated with both types of talc in vitro. Measurements and Results: Interleukin-8, tumor necrosis factor-¿, vascular endothelial growth factor, basic fibroblast growth factor and thrombin-antithrombin complex were measured in all samples. Early death (<7 days after talc) occurred in 8 of 103 patients in the ST and in 1 of 124 in the 'large-particle talc' group (p = 0.007). Patients who received ST had significantly higher proinflammatory cytokines in pleural fluid and serum after talc application, and also in supernatants of the in vitro study. Pleural tumor burden correlated positively with proinflammatory cytokines in serum, suggesting that advanced tumor states induce stronger systemic reactions after talc application. Conclusions: ST provokes a strong inflammatory reaction in both pleural space and serum, which is associated with a higher rate of early deaths observed in patients receiving it. Copyright © 2012 S. Karger AG, Basel.Peer Reviewe

Impacto de estrategias de adquisición de vocabulario en primer año de inglés.

En el contexto de la problemática de la adquisición de vocabulario es pertinentepreguntarse si no existen rutas metodológicas factibles de ser aplicadas sistemáticamente en el aula para mejorar el léxico. Más específicamente, este proyecto, que se llevó a cabo en el año 2017, pretendió demostrar que los alumnos entrenados en el uso de estrategias de aprendizaje mejorarían su competencia léxica, la cual se reflejaría en la incorporación del vocabulario específico de las unidades temáticas enseñadas en clase. Partiendo de la hipótesis que los alumnos que reciban instrucción en el uso de estrategias de aprendizaje demostrarán una capacidad léxica más rica y específica en el empleo de nuevos vocablos, se planteó como objetivo general verificar si la instrucción sistemática en el uso de estrategias de aprendizaje facilitaba la adquisición de vocabulario. El estudio fue de corte cuasi experimental y las variables que se examinaron son la instrucción en las estrategias de aprendizaje de vocabulario (estrategias de memoria y cognitivas) seleccionadas para la ocasión (la variable independiente) y la mejora en la capacidad léxica de losestudiantes (la variable dependiente). La propuesta es repasar el trabajo realizado por el equipo y compartir los resultados y las conclusiones a las que se arribó

“La dislexia en el proceso de enseñanza - aprendizaje”

The didactic pedagogical process is developed as the space, in which students are the ones who build knowledge from reading, contributing their experiences and reflecting on them, exchanging their view points with their classmates and the teacher. However, within this process there are students what confuse letters, have reading problems and present mirror writing, these aspects affect the reading behavior functionality and it prevents to the subject extracts from correctly and efficiently written information and, therefore, affect to their academic, personal and social adaptation. The research pretends to identify dyslexia for determining the impact on the EGB seventh year children teaching-learning process, parallel "B" from "14 de Octubre - Vicente Rocafuerte" Educational Unit, from Pujilí canton, Cotopaxi province, school year 2022-2023. It was performed by qualitative and quantitative research, inductive method, with the interview technique and the psycho-pedagogical test, each one with its respective instrument, the interview guide and the questionnaire. The data was collected to support and justify the purpose of the research with the got information from the researched subjects. Regarding the results, they were analyzed the collected information from the informants, so, were extracted the keywords, categories and subcategories. Therefore, among the main results, they are noted the information taken from the Specific Dyslexia Exploration Test application, which is divided into two areas, the first called reading level that it was got, what students 42% have marked errors as regards to the identification letter names and sounds, and different levels syllables pronunciation, including phonograms and diphthongs. On the other hand, in the test second area called specific errors, it was evidenced that students 38% have reading difficulties, therefore, they confuse and invert letters and syllables within words. This project is essential because it allows, what teachers know the dyslexia disorder, since it is the premature diagnosis subject responsible this learning difficulty in the childhood. In this sense, the teacher must be updated, as regards methodological strategies for the backing the children's literacy development and avoid students academic regression with dyslexia.El proceso pedagógico didáctico se concibe como el espacio en el cual los alumnos son quienes construyen el conocimiento a partir de la lectura, de aportar sus experiencias y reflexionar sobre ellas, de intercambiar sus puntos de vista con sus compañeros y el profesor. Sin embargo, dentro de este proceso existen estudiantes que confunden las letras, tienen problemas al leer y presentan escritura en espejo, estos aspectos afectan la funcionalidad de la conducta lectora e impide al sujeto extraer correcta y eficazmente la información escrita y, por tanto, afecta a su adaptación académica, personal y social. La investigación pretende Identificar la dislexia para la determinación del impacto en el proceso de enseñanza aprendizaje de los niños del Séptimo año de EGB, paralelo “B” de la Unidad Educativa “14 de Octubre – Vicente Rocafuerte”, del cantón Pujilí, provincia de Cotopaxi, año lectivo 2022-2023.Se lo realizó mediante la investigación cualitativa y cuantitativa, método inductivo, con la técnica de la entrevista y el test psicopedagógico, cada uno con su respectivo instrumento, la guía de entrevista y el cuestionario. Los datos fueron recolectados para dar soporte y fundamentar el propósito de la investigación con la información obtenida de los sujetos investigados. En cuanto a los resultados se analizó la información recolectada de los informantes, para ello se extrajo las palabras claves, categorías y subcategorías. Por tanto, entre los principales resultados, se destaca la información tomada de la aplicación del Test de Exploración de Dislexia Específica, el cual, se divide en dos áreas, la primera denominada nivel de lectura, en la cual se obtuvo que el 42% de los estudiantes tienen errores marcados en cuanto a la identificación de nombres y sonidos de letras, y la pronunciación de silabas de distinto nivel incluyendo fonogramas y diptongos. Por otro lado, en la segunda área del test denominado errores específicos se evidenció que el 38% de los estudiantes tienen dificultades en la lectura, por lo que, confunden e invierten letras y sílabas dentro de las palabras. Este proyecto es esencial porque permite que los docentes conozcan el trastorno de la dislexia, pues, es el sujeto responsable del diagnóstico temprano de esta dificultad de aprendizaje en la infancia. En tal virtud, el docente debe estar actualizado en cuanto a estrategias metodológicas para el apoyo en el desarrollo de la lectoescritura de los niños y evitar el retroceso académico de los estudiantes que padecen dislexia

Los procesos de socialización como estrategia de convivencia en el sistema educativo actual

The implementation of socialization processes as a methodological strategy based on the game to strengthen the processes of school coexistence in the current education system, the development, and implementation of these strategies in learning-teaching processes in children has led to significant changes within the academic life, which has brought significant changes within the education, especially in all socio-affective and educational relationships between children and school teacher; these factors indeed, have therefore improved intraand extracurricular school coexistence processes. The research aimed to design and implement a program of methodological strategies based on the game, which allowed to improve the processes of socialization and school coexistence in the current educational system. In this way, a quantitative-qualitative methodological design was used by applying techniques and instruments as a Likert scale questionnaire and a qualitative technique, as checklist sheets applied to teachers and children of fifth years of Basic Education of the Ana Páez Educational Institution of the Parish Eloy Alfaro. These allowed the establishment of the research conclusions and recommendations that relate to the perceptions of school coexistence about the construct of socialization processes wherein the lack of training and guidance for the management of school conflicts were established. Besides, it found that the students of fifth years of Basic Education showed a significant change about the behavior towards their classmates, that is, opinions and working groups were respected as well as solidarity was also pointed out, but overall school coexistence and the relationship between classmates and the teacher were strengthened.La implementación de procesos de socialización como estrategia metodológica basada en el juego para fortalecer los procesos de convivencia escolar en el sistema educativo actual, el desarrollo y la aplicación de estas estrategias en los procesos de enseñanza aprendizaje en los niños ha conllevado grandes cambios dentro del convivir educativo, lo que ha conllevado ha importantes cambios dentro de las relaciones socio educativas y sobre todo afectivas entre los niños y los docentes de la institución educativa, y por consiguiente han mejorado los procesos de convivencia escolar intra y extracurriculares. La presente investigación, tuvo como objetivo el diseñar y aplicar un programa de estrategias metodológicas basadas en el juego que permitió mejorar los procesos de socialización y convivencia escolar en el sistema educativo actual. Para lo que se desarrolló a través del diseño metodológico cuanti-cualitativo, aplicando técnicas e instrumentos como el cuestionario con escalamiento tipo Liker y la técnica cualitativa ficha de observación las mismas que fueron aplicadas a docentes y niños de 5tos años de Educación Básica de la Unidad Educativa Ana Páez de la parroquia Eloy Alfaro, lo que permitió el establecimiento de las conclusiones y recomendaciones, que están en relación con el constructo de los procesos de socialización, donde se pudo establecer la falta de capacitación y orientación a los docentes para el manejo de conflictos escolares, además se pudo evidenciar que los estudiantes de quinto año Educación Básica tuvieron un cambio significativo en referencia a su comportamiento y su conducta hacia los demás compañeros, porque se respetó las opiniones, y la participación en trabajos conjuntos, como también se notó la solidaridad y sobre todo se fortaleció la convivencia escolar y la relación entre compañeros y el docent

Mutation S110L of H1N1 Influenza Virus Hemagglutinin: A Potent Determinant of Attenuation in the Mouse Model

Characterization of a pandemic 2009 H1N1 influenza virus isolated from a fatal case patient (F-IAV), showed the presence of three different mutations; potential determinants of its high pathogenicity that were located in the polymerase subunits (PB2 A221T and PA D529N) and the hemagglutinin (HA S110L). Recombinant viruses containing individually or in combination the polymerase mutations in the backbone of A/California/04/09 (CAL) showed that PA D529N was clearly involved in the increased pathogenicity of the F-IAV virus. Here, we have evaluated the contribution of HA S110L to F-IAV pathogenicity, through introduction of this point mutation in CAL recombinant virus (HA mut). The HA S110L protein has similar pH stability, comparable mobility, and entry properties both in human and mouse cultured cells that wild type HA. The change HA S110L leads to a non-significant trend to reduce the replication capacity of influenza virus in tissue culture, and HA mut is better neutralized than CAL virus by monoclonal and polyclonal antibodies against HA from CAL strain. In addition, recombinant viruses containing HA S110L alone or in combination with polymerase mutations considerably increased the LD50 in infected mice. Characterization of the lungs of HA mut infected animals showed reduced lung damage and inflammation compared with CAL infected mice. Accordingly, lower virus replication, decreased presence in bronchioli and parenchyma and lower leukocytes and epithelial infected cells were found in the lungs of HA mut-infected animals. Our results indicate that, mutation HA S110L constitutes a determinant of attenuation and suggest that its interaction with components of the respiratory tract mucus and lectins, that play an important role on influenza virus outcome, may constitute a physical barrier impeding the infection of the target cells, thus compromising the infection outcome

EVALUACIÓN DE COLOR DEL GARBANZO (Cicer arietinum L.) POR MÉTODOS INSTRUMENTALES Y SENSORIALES

Chickpea is a well recognized source of vegetable protein, especially in underdeveloped areas of the world. Mexican chickpea is highly priced in the international market due to its desired quality. The Northwest of Mexico, especially Sonora and Sinaloa, are also recognized for the quality of chickpea, where a high percentage of the annual production is placed in the international market. Among the various characteristics of high-quality chickpea, color is one of the most important, since it influences both: the selection of new improved varieties at the experimental research stations, and also the price at the international market. The purpose of this study was to evaluate two objective instrumental methods of color determination as related to sensory evaluation analysis, using a panel of trained judges. The color determination method with the highest correlation with sensory evaluation results could be used for the implementation of a color scale for chickpeas. Results from this study will help the improvement selection programs at the agriculture experimental stations for the selection of chickpea varieties with better color quality attributes and also it will increase the commercialization of chickpea produced in the Northwest of Mexico. Ten chickpea samples were selected for this study: seven were chickpea varieties and three were advanced lines, under improved selection programs. Samples were measured by the reflectometer, AGTRON (Md. M300A) and Hunter Lab. apparatus. Sensory evaluation analyses were conducted using a ranking test, where a trained panel of twelve judges ranked chickpea samples in their preference of color. Statistical analyses of variance showed a significantly high correlation between objective and subjective methodologies for color determination.Chickpeas, color, instrumental methods, sensory evaluation., Agribusiness,

Caracterización de las afecciones mamarias en el Policlínico Universitario "Nguyen Van Troi"

Introducción: Son numerosos los procesos patológicos benignos y malignos que pueden afectar el tejido mamario. Objetivo: Caracterizar la incidencia de las afecciones mamarias diagnosticadas en pacientes pertenecientes al Grupo Básico de Trabajo (GBT) No. 2 del Policlínico Universitario "Nguyen Van Troi". Métodos: Se realizó un estudio descriptivo de corte transversal en el Policlínico Universitario "Nguyen Van Troi", de enero a diciembre de 2019, con un universo de 75 mujeres con afecciones mamarias. Se analizaron variables como: edad, menarquia, menopausia, historia obstétrica, primer parto, lactancia materna, conocimientos sobre autoexamen de mamas, diagnóstico definitivo. Se utilizaron métodos de análisis propios de la estadística descriptiva. Resultados: Predominaron las afecciones mamarias benignas (84 %), en mujeres de 40 a 49 años (29,3 %), con menarquia entre 11 y 13 años de edad (42,6 %) y la displasia mamaria cíclica fue la más común (38,6 %). Las afecciones malignas (16 %) prevalecieron en mujeres de 50 a 59 años (10,6 %), nulíparas (66,6 %) y primer parto después de los 35 años (58,3). El 82,6 % de las pacientes conocían del autoexamen de mamas, y solo el 8,06 % lo realizaba cada mes. Conclusiones: La caracterización arrojó predominio de afecciones benignas en mujeres de 40 a 49 años, y la displasia mamaria cíclica fue la más común. Las afecciones malignas prevalecieron en mujeres de 50 a 59 años, nulíparas y primer parto posterior a los 35 años. La mayoría de las pacientes tenían conocimientos sobre el autoexamen de mamas, pero pocas lo realizaban mensualmente